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CHEMOTAXIS, OLFACTION MODELLING, MORPHOGENESIS & EMBRYOGENESIS
JULIE BATUT
RESEARCH PROJECTS

Exploring and sharing the wonders of science

ABOUT

I became a researcher in 2008. Since then, my interests have focused on embryonic development. Understanding the mechanisms at work for a functional organism to be generated from the totipotent egg cell. How does the acquisition of a form and an identity enable a specific function? Since 2014, my work has focused on the development of the olfactory sensory organ using the transparency and genetics of the zebrafish embryo combined with multidisciplinary approaches using mathematical modeling (theoretical model), analytical methods quantitative image, data learning and microfluidics (intermediate olfactory model). We are particularly interested in the mechanisms that coordinate morphogenesis (form) and neurogenesis (identity) during the formation of this organ. My research is collaborative, inclusive and multidisciplinary. I am very involved in the development and sharing of an inclusive and multidisciplinary science. We disseminate and share our progress and our questions with the general public thanks to three associations: Femmes & Sciences, Les Chemins Buissonniers and Les Maths en Scène. I invite you to click on the dedicated link for more details. Do not hesitate to contact me for more information on research work, sharing with the public or schools as well as other associative activities.

RESEARCH TOPICS

Understanding organ formation mechanisms

Olfactory sensory organ formation

Morphogenesis & Cell lignage

Organ formation requires fine coordination between several processes to get the right number of cells positioned in the right place with the right shape to orient to the right identity and form a functional organ.

Using the zebrafish embryo, we combine live imaging and dedicated image analysis tools to understand the morphogenesis of the olfactory epithelium and cell lineages during olfactory organ formation.

We collaborate with Christian Rouvière (CBI image analysis platform).

Modelling Olfactory Organ Formation

In collaboration with Gaëlle Letort (Institut Pasteur, Paris), Violaine Roussier-Michon and David Sanchez (INSA, Toulouse), an agent-based model is used and developed to model olfactory morphogenesis.

Toutes les vidéos

Toutes les vidéos

Toutes les vidéos
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Olfactory_nlsEos_neurog1:GFP_cxcr4b-mkate

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Us

Here is the MultiModal Modelling of Organ Development in Zebrafish Team with Patrick Blader

Publications related to our work

Publications of interest

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Patterning, morphogenesis, and neurogenesis of zebrafish cranial sensory placodes

Aguillon R, Blader P, Batut J. Patterning, morphogenesis, and neurogenesis of zebrafish cranial sensory placodes. Methods Cell Biol. 2016;134:33-67. doi: 10.1016/bs.mcb.2016.01.002. Epub 2016 Feb 28. PMID: 27312490.

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Aguillon R, Madelaine R, Aguirrebengoa M, Guturu H, Link S, Dufourcq P, Lecaudey V, Bejerano G, Blader P, Batut J. Morphogenesis is transcriptionally coupled to neurogenesis during peripheral olfactory organ development. Development. 2020 Dec 21;147(24):dev192971. doi: 10.1242/dev.192971. PMID: 33144399.

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Aguillon R, Batut J, Subramanian A, Madelaine R, Dufourcq P, Schilling TF, Blader P. Cell-type heterogeneity in the early zebrafish olfactory epithelium is generated from progenitors within preplacodal ectoderm. Elife. 2018 Jan 2;7:e32041. doi: 10.7554/eLife.32041. PMID: 29292696; PMCID: PMC5749950.

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Batut J, Kvaskoff M, Morris MC. When mentoring matters: a French mentoring program for women in science. Nat Biotechnol. 2021 Jun;39(6):776-779. doi: 10.1038/s41587-021-00951-2. PMID: 34113043.

Supports

Parallel Lines
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Associations

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CONTACT

julie.batut(at)univ-tlse3.fr

05 62 55 65 71

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